The Bills enter the game 10-2 and have a healthy lead atop the AFC East, but are battling the Kansas City Chiefs (11-1) for the top playoff seed in the AFC. The Rams, meanwhile, are 6-6 and in the middle of a tough playoff race in the NFC West, with all four teams within two games of each other in the standings.
Tom Brady will be on the call for the game, providing insight from the booth, while FOX Sports NFL writer Henry McKenna will share his analysis live throughout this game.
Check out below for all the biggest plays from the game.
1:54p ET
Preview: Bills, Rams both eye improved playoff position, just from different angles
Live Coverage for this began on 3:30p ET
