NFL Week 4 kicks off Thursday night, as the Cardinals Bills host the Seahawks.
Here are the lines for every Week 4 matchup at DraftKings Sportsbook as of Sept. 21.
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(All times ET)
2025 NFL Week 4 Odds
THURSDAY, SEPT. 25
Spread: Cardinals -1.5
Moneyline: Cardinals -122, Seahawks +102
Total O/U: 43.5
SUNDAY, SEPT. 28
Spread: Vikings -1.5
Moneyline: Vikings -125, Steelers +105
Total O/U: 41.5
Spread: Commanders -3
Moneyline: Commanders -155, Falcons +130
Total O/U: 45.5
Spread: Bills -15.5
Moneyline: Bills -1600, Saints +900
Total O/U: 48.5
Spread: Lions -8.5
Moneyline: Lions -380, Browns +300
Total O/U: 45.5
Spread: Patriots -4.5
Moneyline: Patriots -205, Panthers +170
Total O/U: 45.5
Spread: Chargers -6
Moneyline: Chargers -278, Giants +225
Total O/U: 44.5
Spread: Eagles -2.5
Moneyline: Eagles -155, Bucs +130
Total O/U: 45.5
Spread: Texans -7
Moneyline: Texans -355, Titans +280
Total O/U: 40.5
Spread: Rams -4.5
Moneyline: Rams -205, Colts +170
Total O/U: 47.5
Spread: 49ers -4.5
Moneyline: 49ers -205, Jaguars +170
Total O/U: 45.5
Spread: Ravens -2.5
Moneyline: Ravens -142, Chiefs +120
Total O/U: 49.5
Spread: Bears -1.5
Moneyline: Bears -115, Raiders -105
Total O/U: 46.5
Spread: Packers -5.5
Moneyline: Packers -250, Cowboys +205
Total O/U: 48.5
MONDAY, SEPT. 29
Spread: Dolphins -2.5
Moneyline: Dolphins -148, Jets +124
Total O/U: 45.5
Spread: Broncos -7.5
Moneyline: Broncos -375, Bengals +295
Total O/U: 44.5
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