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The weekend’s only top 25 matchups is here, and there’s plenty of eyes on Louisville vs. Ole Miss. No. 9 Ole Miss brings Trinidad Chambliss and Kewan Lacy into Nashville, while No. 24 Louisville counters with dynamic running back Isaac Brown and coach Jeff Brohm looking to pull off the upset.
The action doesn’t stop there. No. 4 Notre Dame takes on Wisconsin at Lambeau Field in another marquee matchup, giving you another high-profile game to trade on. With ranked teams, star players and plenty of potential upsets across the slate, there are opportunities to get involved throughout the weekend.
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Biggest Games of Week 1
*Probabilities are subject to change*
No. 9 Ole Miss vs. No. 24 Louisville
| Teams | Chance | Yes | No |
| Ole Miss Rebels | 70% | 70¢ | 31¢ |
| Louisville Cardinals | 31% | 31¢ | 70¢ |
No. 4 Notre Dame vs. Wisconsin
| Teams | Chance | Yes | No |
| Notre Dame Fighting Irish | 92% | 92¢ | 9¢ |
| Wisconcsin Bagers | 8% | 9¢ | 92¢ |
Monday: No. 19 SMU vs. Florida State
| Teams | Chance | Yes | No |
| SMU Mustangs | 61% | 61¢ | 40¢ |
| Florida State Seminoles | 40% | 40¢ | 61¢ |
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